H2HA A/Japan/305/1957 complexed with mouse polyclonal Fab - wk 12, reoriented immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
H2HA A/Japan/305/1957 complexed with mouse polyclonal Fab - wk 12, control immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
- Polyclonal fab (Complex from Mus musculus)
- Influenza a virus (a/japan/305/1957(h2n2)) (Complex from Influenza A virus (A/Japan/305/1957(H2N2)))
- H2ha a/japan/305/1957 (Protein)
- H2ha a/japan/305/1957 immune complex with mouse polyclonal fab - week 12, control immunogen group (Complex)
H7N9 A/Shanghai/2/2013 complexed with mouse polyclonal Fab - wk 12, control immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
H3N2 A/Victoria/3/1975 complexed with mouse polyclonal Fab - wk 7, control immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
- Polyclonal fab (Complex from Mus musculus)
- H3n2 a/victoria/3/1975 (Protein from Influenza A virus (A/Victoria/3/1975(H3N2)))
- H3n2 a/victoria/3/1975 (Complex from Influenza A virus (A/Victoria/3/1975(H3N2)))
- H3n2 a/victoria/3/1975 immune complex with mouse polyclonal fab - week 7, control immunogen group (Complex)
H3N2 A/Victoria/3/1975 complexed with mouse polyclonal Fab - wk 7, reoH2HA immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
H7N9 A/Shanghai/2/2013 complexed with mouse polyclonal Fab - wk 7, reoriented immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
H7N9 A/Shanghai/2/2013 complexed with mouse polyclonal Fab - wk 7, control immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
H7N9 A/Shanghai/2/2013 complexed with mouse polyclonal Fab - wk 7, reoriented immunogen
Xu D, Carter JJ, Li C, Utz A, Weidenbacher PAB, Tang S, Sanyal M, Pulendran B, Barnes CO, Kim PS
Nat Chem Biol (2024) [ Pubmed: 38225471 DOI: doi:10.1038/s41589-023-01529-6 ]
S1V2-72 Fab bound to EHA2 from influenza B/Malaysia/2506/2004
Resolution: 4.98 Å
EM Method: Single-particle
Fitted PDBs: 8udg
Q-score: 0.202
Finney J, Moseman AP, Kong S, Watanabe A, Song S, Walsh Jr RM, Kuraoka M, Kotaki R, Moseman EA, McCarthy KR, Liao D, Liang X, Nie X, Lavidor O, Abbott R, Harrison SC, Kelsoe G
PNAS (2024) 121 pp. e2316964120-e2316964120 [ Pubmed: 38147556 DOI: doi:10.1073/pnas.2316964120 ]
- Hemagglutinin (17 kDa, Protein from Influenza B virus (B/Malaysia/2506/2004))
- S1v2-72 heavy chain (24 kDa, Protein from Homo sapiens)
- Complex of two s1v2-72 fabs with postfusion ha2 (Complex from Influenza B virus (B/Malaysia/2506/2004))
- S1v2-72 light chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 8d21
Q-score: 0.395
Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA, Gorman J, Raab JE, Brand J, Creanga A, Gajjala SR, Narpala S, Cheung CSF, Harris DR, Zhou T, Gordon I, Holman L, Mendoza F, Houser KV, Chen GL, Mascola JR, Graham BS, Kwong PD, Widge A, Dropulic LK, Ledgerwood JE, Kanekiyo M, McDermott AB
Sci Transl Med (2023) 15 pp. eade4976-eade4976 [ DOI: doi:10.1126/scitranslmed.ade4976 Pubmed: 37075126 ]
- Cryo-em structure of the vrc321 clinical trial, vaccine-elicited, human antibody 1b06 in complex with a stabilized nc99 ha trimer (Complex)
- 1b06 light chain (11 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus)
- 1b06 fab with nc99 ha trimer (Complex from Influenza A virus)
- 1b06 heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)